In the footsteps of giants: New insights into the activation of NLR immune receptors

In this paper, adapted from one of his thesis chapters, Mauricio (Mau) Contreras not only sheds light on a crucial aspect of plant immune receptor activation but also pays tribute to the groundbreaking work of Peter Moffett and other scientists who made a remarkable and oft overlooked observation two decades ago. Indeed, good science stands the test of time.

Read Mauricio’s X / Twitter thread here.

Contreras, M.P., Pai, H., Thompson, R., Claeys, J., Adachi, H., and Kamoun, S. 2023. The nucleotide binding domain of NRC-dependent disease resistance proteins is sufficient to activate downstream helper NLR oligomerization and immune signaling. bioRxiv, doi: https://doi.org/10.1101/2023.11.30.569466.